Product Overview:
JXL-069 is formulated at 0.5 mg/mL (15 mg per 30 mL bottle) in the MODS MAX™ advanced mineral carrier. This potent MPC inhibitor is optimized for laboratory applications studying cellular metabolism and the activation of hair follicle stem cells, aiming to unlock new approaches for hair regeneration and hair loss treatment.
 
Research Focus:
 
Activating dormant hair follicle stem cells (HFSCs) via metabolic reprogramming
MPC inhibition, which elevates lactate dehydrogenase (LDH) activity and shifts cell metabolism from mitochondrial pyruvate import to cytoplasmic glycolysis
Inducing the transition of hair follicles from the resting (telogen) to growth (anagen) phase
Evaluating the effects on hair follicle cycling, regeneration, and density.
 
Mechanism and Key Findings:
 
MPC inhibition by JXL-069 results in: 
Enhanced lactate production, stimulating HFSC activation
Robust acceleration of the hair growth cycle in animal models
Topical treatment with JXL-069 (and related analogues) on mice in telogen phase led to significant, visible hair regrowth and greater follicular activity within 2 weeks compared to controls. 
 
Recent studies confirm
Novel MPC inhibitors including JXL-069 dramatically stimulate hair growth following topical application in vivo.
Mechanistic studies show MPC blockade leads to upregulation of stem cell proliferation markers (e.g., Ki67) and reactivation of dormant follicles.
 
Reference Research:
Liu X, Flores AA, Situ L, et al. (2021). “Development of novel mitochondrial pyruvate carrier inhibitors to treat hair loss.” J Med Chem, 64(4):2046-2063. Demonstrates JXL-069’s efficacy and mechanism for stimulating hair regrowth via lactate-driven metabolic reprogramming in hair follicle stem cells. pubs.acs+2 2. 
Pelage Pharmaceuticals Phase 1/2 trial data (2025) Topical MPC inhibitors led to >20% increase in hair density in 31% of participants with advanced hair loss—acting faster than minoxidil or finasteride and regenerating new follicles in previously bald scalp areas. nymag+1